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Yes, they should have read your resume and the cover letter you sent in, but that only gave them enough information for them to want to see you in person Now you are going to meet the hiring manager in person, you have a one-off make or break opportunity to get them to see you as the only person they want to employ.
As you know, interviewers will often rely heavily on their first impressions, to the extent that the interview becomes merely a confirmation of that first impression, either good or bad.
So if self-introduction is your key to interview success, the first and most important aim is to create a positive first impression. Everybody has an opinion as to how you do that: look 'em in the eye, give 'em a firm handshake speak up and don't mumble; know your stuff. All good ideas, but what do you actually do and what do you say?